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Neuropsychological
Outcome in Survivors of Childhood Brain Tumors
Pediatric brain tumors can result in extensive neuropsychological deficits
for some individuals because of their invasive impact on the developing
brain. Research suggests that young adult brain tumor survivors may experience
delayed processing speed and executive functioning strategies, impairing
their ability to be successful at school, work, and activities of daily
living. Deficits in processing speed and executive functioning may not be
apparent during childhood when accommodations can be made at school or with
parental supervision. The aims of this study are to: 1. Determine processing
speed and executive functioning in young adult survivors of childhood brain
tumors; and 2. Compare differences in cognitive outcomes between survivors
treated with whole brain irradiation vs. partial brain irradiation vs. surgery
alone. This study can form the beginning of an understanding of the late
effects from early treatment in the functional trajectory of the developing
brain. Furthermore, the results can potentially provide a basis for studies
of basic mechanisms accounting for these late effects as well as cognitive
outcome goals for newer therapies. |